Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21657
Título: Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species
Autor: Wesolowska, Olga
Wisniewski, Jerzy
Duarte, Noelia
Ferreira, Maria-Jose U.
Michalak, Krystyna
Palavras-chave: Oncology
Data: 2007
Editora: INT INST ANTICANCER RESEARCH
Citação: ANTICANCER RESEARCH. - Vol. 27, n. 6B (NOV-DEC 2007), p. 4127-4133
Resumo: Background: A search for inhibitors of multidrug resistance (MDR)-associated protein 1 (MRP1) was performed among the compounds isolated from Euphorbia species, plants traditionally used in folk medicine. Materials and Methods: Fifteen compounds with terpenic or phenolic structures (macrocyclic and polycyclic diterpenes, coumarins, stilbenes and flavonoids) were isolated from the methanol extracts of Euphorbia lagascae and Euphorbia tuckeyana or obtained by derivatization. A functional test based on measuring the efflux of fluorescent MRP1 substrate (BCECF) from human erythrocytes was employed. Results: Effective MRP1 inhibitors were identified among the stilbenes (piceatannol and its derivatives) and the flavonoids (aromadendrin, naringenin and its derivatives). Conclusion: Euphorbia species constitute a promising source of multidrug resistance modulators.
URI: http://hdl.handle.net/10451/21657
ISSN: 0250-7005
Aparece nas colecções:FF - Produção Científica 2000-2009

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