Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21730
Título: Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neurons
Autor: Vaz AR, Leitão Silva S,
Data: 2009
Editora: Frontiers
Resumo: The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may produce neuropathological sequelae [4]. Therefore, the aim of the present study was to: (i) deepen characterize the mechanisms of neuronal apoptosis upon cytokine exposure in neuronal immature cells; and (ii) investigate the role of NO as a determinant.
URI: http://hdl.handle.net/10451/21730
Aparece nas colecções:FF - Produção Científica 2000-2009

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