Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/23253
Título: Cell-penetrating peptides: a tool for effective delivery in gene-targeted therapies
Autor: Figueiredo, Inês Rego de
Freire, João Miguel
Flores, Luís
Veiga, Ana Salomé
Castanho, Miguel A. R. B.
Palavras-chave: Cell-penetrating peptide
Gene therapy
Cancer treatment
Drug delivery
Data: 2014
Editora: Wiley
Citação: 2014 International Union of Biochemistry and Molecular Biology, Volume 66, Number 3, March 2014, Pages 182–194
Resumo: The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cells, which may pose difficult tasks to pharmaceutical companies. To overcome this technological limitation, a wide variety of vectors have been developed in the past decades and have proven to be successful in delivering various therapeutics. Cell-penetrating peptides (CPP) have been one of the technologies widely studied and have been increasingly used to transport small RNA/DNA, plasmids, antibodies, and nanoparticles into cells. Despite the already proved huge potential that these peptide-based approaches may suggest, few advances have been put to pharmacological or clinical use. This review will describe the origin, development, and usage of CPP to deliver therapeutic agents into cells, with special emphasis on their current application to gene-therapies. Specifically, we will describe the current trials being conducted to treat cancer, gene disorders, and autoimmune diseases using CPP-based therapies.
Descrição: © 2014 International Union of Biochemistry and Molecular Biology
Peer review: yes
URI: http://hdl.handle.net/10451/23253
DOI: DOI 10.1002/iub.1257
ISSN: 1521-6543
Versão do Editor: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-6551/
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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