Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/23553
Título: Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120
Autor: Matos, Pedro M.
Andreu, David
Santos, Nuno C.
Gutiérrez-Gallego, Ricardo
Palavras-chave: HIV-1
gp120
Viral attachment
Heparan sulfate proteoglycans
Glycosaminoglycans
Surface plasmon resonance
Data: 2014
Editora: Springer
Citação: Arch Virol (2014) 159:555–560
Resumo: Heparan sulfate proteoglycans are known to assist HIV-1 entry into host cells, mediated by the viral envelope glycoprotein gp120. We aimed to determine the general structural features of glycosaminoglycans that enable their binding to gp120, by surface plasmon resonance. Binding was found to be dependent on sequence type, size and sulfation patterns. HIV-1 gp120 prefers heparin and heparan sulfate (with at least 16 monomers in length) over chondroitin and dermatan. Sulfate groups were essential to promote this interaction. These results advance the understanding of the molecular-level requirements for virus attachment and cell entry.
Descrição: © Springer-Verlag Wien 2013
Peer review: yes
URI: http://hdl.handle.net/10451/23553
DOI: 10.1007/s00705-013-1831-3
ISSN: 0304-8608
Versão do Editor: http://link.springer.com/journal/705
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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