Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/28742
Título: Gyrfalcons Falco rusticolus adjust CTNS expression to food abundance: a possible contribution to cysteine homeostasis
Autor: Galván, Ismael
Inácio, Ângela
Nielsen, Ólafur K.
Palavras-chave: CTNS 
Cysteine homeostasis
Food abundance
Gyrfalcon 
Pheomelanin
Data: 2017
Citação: Oecologia (2017) 184:779–785
Resumo: Melanins form the basis of animal pigmentation. When the sulphurated form of melanin, termed pheomelanin, is synthesized, the sulfhydryl group of cysteine is incorporated to the pigment structure. This may constrain physiological performance because it consumes the most important intracellular antioxidant (i.e., glutathione, GSH), of which cysteine is a constitutive amino acid. However, this may also help avoid excess cysteine, which is toxic. Pheomelanin synthesis is regulated by several genes, some of them exerting this regulation by controlling the transport of cysteine in melanocytes. We investigated the possibility that these genes are epigenetically labile regarding protein intake and thus contribute to cysteine homeostasis. We found in the Icelandic population of gyrfalcon Falco rusticolus, a species that pigments its plumage with pheomelanin, that the expression of a gene regulating the export of cystine out of melanosomes (CTNS) in feather melanocytes of developing nestlings increases with food abundance in the breeding territories where they were reared. The expression of other genes regulating pheomelanin synthesis by different mechanisms of influence on cysteine availability (Slc7a11 and Slc45a2) or by other processes (MC1R and AGRP) was not affected by food abundance. As the gyrfalcon is a strict carnivore and variation in food abundance mainly reflects variation in protein intake, we suggest that epigenetic lability in CTNS has evolved in some species because of its potential benefits contributing to cysteine homeostasis. Potential applications of our results should now be investigated in the context of renal failure and other disorders associated with cystinosis caused by CTNS dysfunction.
Descrição: © Springer-Verlag GmbH Germany 2017
Peer review: yes
URI: http://hdl.handle.net/10451/28742
DOI: 10.1007/s00442-017-3920-6
ISSN: 1432-1939
Versão do Editor: https://link.springer.com/journal/442
Aparece nas colecções:FM-ISAMB-Artigos em Revistas Internacionais

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