Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/32127
Título: Off-label prescribing : scientific analysis taking the use of bevacizumab in ophthalmology as an example
Outros títulos: Prescrição off-label: análise científica tendo como exemplo a utilização de Bevacizumab em oftalmologia
Autor: Alarcão, Joana
Costa, João
Fareleira, Filipa
Borges, Margarida
Carneiro, António Vaz
Palavras-chave: Antibodies, Monoclonal, Humanized
Macular Degeneration
Macular Edema
Retinal Vein Occlusion
Off-Label Use
Data: 2013
Editora: Acta Médica Portuguesa
Citação: Acta Med Port 2013 Jul-Aug;26(4):409-419
Resumo: Off-label prescribing poses specific technical/scientific, professional and ethical problems. In this study we carry out a technical and scientific analysis of the off-label prescribing using a current, clinical and economically relevant example: the paradigmatic case of the use of bevacizumab in ophthalmologic pathologies for which it has no formal indication. We conducted a systematic review of the literature on the efficacy and safety of this drug, as well as ranibizumab - which has approved ophthalmologic indications, in order to qualitatively analyze the available evidence on the two interventions. This is a typical case for technical and scientific analysis of the off-label prescribing problems. According to the results of the systematic review, the use of bevacizumab in this context has in fact scientific evidence of appreciable size, including clinical trials head-to-head with ranibizumab. However, the identified safety issues raise the question of the use of this drug in ophthalmologic pathologies. The different players involved in the treatment decisions (physicians, patients and institutional decision makers) should be adequately informed about the existing evidence that supports off-label prescribing which, by definition, must always be on an exceptional basis and properly justified.
Peer review: yes
URI: http://hdl.handle.net/10451/32127
ISSN: 1646-0758
Versão do Editor: https://www.actamedicaportuguesa.com/
Aparece nas colecções:FM-CEMBE-Artigos em Revistas Nacionais

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