Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/32819
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degois.publication.firstPage14897pt_PT
degois.publication.issue39pt_PT
degois.publication.lastPage14906pt_PT
degois.publication.titleNanoscalept_PT
dc.relation.publisherversionhttp://pubs.rsc.org/en/Journals/JournalIssues/NR#!recentarticles&advpt_PT
dc.contributor.authorGuedes, Ana F.-
dc.contributor.authorCarvalho, Filomena A.-
dc.contributor.authorMoreira, Carlos-
dc.contributor.authorNogueira, José B.-
dc.contributor.authorSantos, Nuno C.-
dc.date.accessioned2018-04-16T13:49:07Z-
dc.date.available2018-04-16T13:49:07Z-
dc.date.issued2017-
dc.identifier.citationNanoscale, 2017, 9, 14897–14906pt_PT
dc.identifier.issn2040-3364-
dc.identifier.urihttp://hdl.handle.net/10451/32819-
dc.description© The Royal Society of Chemistry 2017pt_PT
dc.description.abstractThe increase of erythrocyte aggregation by high fibrinogen levels may be an indicator of cardiovascular risk. γ' fibrinogen variant has been considered as a possible player in enhancing aggregation. Here, we assessed, at the single-cell level, the influence of fibrinogen on erythrocyte aggregation in essential arterial hypertension. We also aimed at understanding how γ' fibrinogen is altered in this disease. Using atomic force microscopy (AFM), we show that the work and force necessary for erythrocyte-erythrocyte detachment is higher for patients than for healthy donors, with these parameters further increasing in both groups when higher fibrinogen concentrations are present. This can be associated with changes in blood flow, due to transient bridging of two erythrocytes by fibrinogen, representing an important cardiovascular risk factor. γ' fibrinogen can influence the increased risk in essential arterial hypertension, as we demonstrate that its levels are significantly increased in these patients' blood. Nevertheless, this cannot be the only cause for the changes observed in the AFM data.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) grants PTDC/QUI-BIQ/119509/2010 and PTDC/BBB-BMD/6307/2014, as well as the fellowship SFRH/BD/84414/2012 to AFG.pt_PT
dc.language.isoengpt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationPTDC/QUI-BIQ/ 119509/2010pt_PT
dc.relationPTDC/BBB-BMD/6307/2014pt_PT
dc.relationSFRH/BD/84414/2012pt_PT
dc.rightsrestrictedAccesspt_PT
dc.titleEssential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular riskpt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume9pt_PT
dc.identifier.doi10.1039/c7nr03891gpt_PT
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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