Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/32820
Title: Peptides with dual antimicrobial and anticancer activities
Author: Felício, Mário R.
Silva, Osmar N.
Gonçalves, Sónia
Santos, Nuno C.
Franco, Octávio L.
Keywords: Anticancer peptides (ACPs)
Antimicrobial peptides (AMPs)
Cancer
Multi-resistant infections
Bacteria
Issue Date: 2017
Publisher: Frontiers Media
Citation: Front. Chem. 5:5
Abstract: In recent years, the number of people suffering from cancer and multi-resistant infections has increased, such that both diseases are already seen as current and future major causes of death. Moreover, chronic infections are one of the main causes of cancer, due to the instability in the immune system that allows cancer cells to proliferate. Likewise, the physical debility associated with cancer or with anticancer therapy itself often paves the way for opportunistic infections. It is urgent to develop new therapeutic methods, with higher efficiency and lower side effects. Antimicrobial peptides (AMPs) are found in the innate immune system of a wide range of organisms. Identified as the most promising alternative to conventional molecules used nowadays against infections, some of them have been shown to have dual activity, both as antimicrobial and anticancer peptides (ACPs). Highly cationic and amphipathic, they have demonstrated efficacy against both conditions, with the number of nature-driven or synthetically designed peptides increasing year by year. With similar properties, AMPs that can also act as ACPs are viewed as future chemotherapeutic drugs, with the advantage of low propensity to resistance, which started this paradigm in the pharmaceutical market. These peptides have already been described as molecules presenting killing mechanisms at the membrane level, but also acting toward intracellular targets, which increases their success compartively to one-target specific drugs. This review will approach the desirable characteristics of small peptides that demonstrated dual activity against microbial infections and cancer, as well as the peptides engaged in clinical trials.
Description: Copyright © 2017 Felício, Silva, Gonçalves, Santos and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Peer review: yes
URI: http://hdl.handle.net/10451/32820
DOI: 10.3389/fchem.2017.00005
ISSN: 2296-2646
Publisher Version: https://www.frontiersin.org/journals/chemistry
Appears in Collections:IMM - Artigos em Revistas Internacionais

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