Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/32820
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degois.publication.issue5pt_PT
degois.publication.titleFrontiers in Chemistrypt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/chemistrypt_PT
dc.contributor.authorFelício, Mário R.-
dc.contributor.authorSilva, Osmar N.-
dc.contributor.authorGonçalves, Sónia-
dc.contributor.authorSantos, Nuno C.-
dc.contributor.authorFranco, Octávio L.-
dc.date.accessioned2018-04-16T14:06:33Z-
dc.date.available2018-04-16T14:06:33Z-
dc.date.issued2017-
dc.identifier.citationFront. Chem. 5:5pt_PT
dc.identifier.issn2296-2646-
dc.identifier.urihttp://hdl.handle.net/10451/32820-
dc.descriptionCopyright © 2017 Felício, Silva, Gonçalves, Santos and Franco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractIn recent years, the number of people suffering from cancer and multi-resistant infections has increased, such that both diseases are already seen as current and future major causes of death. Moreover, chronic infections are one of the main causes of cancer, due to the instability in the immune system that allows cancer cells to proliferate. Likewise, the physical debility associated with cancer or with anticancer therapy itself often paves the way for opportunistic infections. It is urgent to develop new therapeutic methods, with higher efficiency and lower side effects. Antimicrobial peptides (AMPs) are found in the innate immune system of a wide range of organisms. Identified as the most promising alternative to conventional molecules used nowadays against infections, some of them have been shown to have dual activity, both as antimicrobial and anticancer peptides (ACPs). Highly cationic and amphipathic, they have demonstrated efficacy against both conditions, with the number of nature-driven or synthetically designed peptides increasing year by year. With similar properties, AMPs that can also act as ACPs are viewed as future chemotherapeutic drugs, with the advantage of low propensity to resistance, which started this paradigm in the pharmaceutical market. These peptides have already been described as molecules presenting killing mechanisms at the membrane level, but also acting toward intracellular targets, which increases their success compartively to one-target specific drugs. This review will approach the desirable characteristics of small peptides that demonstrated dual activity against microbial infections and cancer, as well as the peptides engaged in clinical trials.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal), by Brazilian funding agencies CNPq, CAPES, FADPDF, FINEP, and FUNDECT, and by Marie Skłodowska-Curie, Research, and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167). MF acknowledges FCT-MCTES fellowship SPRH/BD/100517/2014. OS holds a postdoctoral scholarship from the National Council of Technological and Scientific Development (CNPq) and Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT; 300583/2016-8).pt_PT
dc.language.isoengpt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationSPRH/BD/100517/2014pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnticancer peptides (ACPs)pt_PT
dc.subjectAntimicrobial peptides (AMPs)pt_PT
dc.subjectCancerpt_PT
dc.subjectMulti-resistant infectionspt_PT
dc.subjectBacteriapt_PT
dc.titlePeptides with dual antimicrobial and anticancer activitiespt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume5pt_PT
dc.identifier.doi10.3389/fchem.2017.00005pt_PT
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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