Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/33662
Título: Antiviral lipopeptide-cell membrane Interaction Is Influenced by PEG linker length
Autor: Augusto, Marcelo T.
Hollmann, Axel
Porotto, Matteo
Moscona, Anne
Santos, Nuno C.
Palavras-chave: Antiviral
Data: 2017
Editora: MDPI
Citação: Molecules 2017, 22, 1190
Resumo: A set of lipopeptides was recently reported for their broad-spectrum antiviral activity against viruses belonging to the Paramyxoviridae family, including human parainfluenza virus type 3 and Nipah virus. Among them, the peptide with a 24-unit PEG linker connecting it to a cholesterol moiety (VG-PEG24-Chol) was found to be the best membrane fusion inhibitory peptide. Here, we evaluated the interaction of the same set of peptides with biomembrane model systems and isolated human peripheral blood mononuclear cells (PBMC). VG-PEG24-Chol showed the highest insertion rate and it was among the peptides that induced a larger change on the surface pressure of cholesterol rich membranes. This peptide also displayed a high affinity towards PBMC membranes. These data provide new information about the dynamics of peptide-membrane interactions of a specific group of antiviral peptides, known for their potential as multipotent paramyxovirus antivirals.
Descrição: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Peer review: yes
URI: http://hdl.handle.net/10451/33662
DOI: 10.3390/molecules22071190
ISSN: 1420-3049
Versão do Editor: http://www.mdpi.com/journal/molecules
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Antiviral_Lipopeptide.pdf615,53 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.