Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/34797
Title: Abnormal myocardial flow reserve in sickle cell disease : a myocardial contrast echocardiography study
Author: Almeida, Ana G.
Arajo, Francisco
Rego, Fernanda
David, Cludio
Lopes, Mrio G.
Soares, J. Ducla
Keywords: Contrast echocardiography
Sickle cell disease
Myocardial perfusion
Ventricular function
Myocardial contrast echocardiography
Issue Date: 2008
Publisher: Blackwell Publishing
Citation: Almeida, A. G., Araújo, F. , Rego, F. , David, C. , Lopes, M. G. and Ducla‐Soares, J. (2008), Abnormal Myocardial Flow Reserve in Sickle Cell Disease: A Myocardial Contrast Echocardiography Study. Echocardiography, 25: 591-599. doi:10.1111/j.1540-8175.2008.00666.x
Abstract: Background: Sickle cell disease (SCD) is characterized by obstruction of microvessels leading to ischemia and necrosis. We have aimed to demonstrate whether myocardial contrast echocardiography (MCE) is able to detect myocardial perfusion abnormalities in SCD patients and to assess their relationship with left ventricle (LV) perfusion and systolic function. Methods: A group of 25 patients with SCD and a control group of 19 normal individuals were studied. Using MCE, myocardial perfusion reserve indices (A, β, and A×β) were obtained, before and after hyperemia with dypiridamole. LV function was also analyzed: ejection fraction (EF), index of myocardial performance (IMP), the ratio of transmitral early-diastolic flow velocity E and the pulsed tissue Doppler mitral annular early diastolic velocity Ea (E/Ea) (E/Ea), tissue Doppler mitral annular peak systolic velocity (Sa), and peak systolic strain (S) were obtained. Results: Myocardial velocity (β) and myocardial blood flow (A×β) reserves were lower in the patients than in controls (1.7 ± 0.4 vs. 3.3 ± 0.2, P = 0.000 and 2.1 ± 0.6 vs. 4.1 ± 0.2, P = 0.000, respectively). In SCD patients, a correlation was found between β reserve and EF, IMP, Sa, E/Ea, and S% and between A×β reserve and Sa. Conclusions: MCE detected abnormal perfusion reserve in patients with SCD, which correlated with systolic function indices. This suggests that perfusion plays a role in SCD ventricular dysfunction.
Description: © 2008, the Authors Journal compilation © 2008, Blackwell Publishing, Inc.
Peer review: yes
URI: http://hdl.handle.net/10451/34797
DOI: 10.1111/j.1540-8175.2008.00666.x
ISSN: 0742-2822
Publisher Version: https://onlinelibrary.wiley.com/journal/15408175
Appears in Collections:FM-CCUL-Artigos em Revistas Internacionais

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