Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/34797
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degois.publication.firstPage591pt_PT
degois.publication.issue6pt_PT
degois.publication.lastPage599pt_PT
degois.publication.titleEchocardiographypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/15408175pt_PT
dc.contributor.authorAlmeida, Ana G.-
dc.contributor.authorArajo, Francisco-
dc.contributor.authorRego, Fernanda-
dc.contributor.authorDavid, Cludio-
dc.contributor.authorLopes, Mrio G.-
dc.contributor.authorSoares, J. Ducla-
dc.date.accessioned2018-09-13T10:47:37Z-
dc.date.available2018-09-13T10:47:37Z-
dc.date.issued2008-
dc.identifier.citationAlmeida, A. G., Araújo, F. , Rego, F. , David, C. , Lopes, M. G. and Ducla‐Soares, J. (2008), Abnormal Myocardial Flow Reserve in Sickle Cell Disease: A Myocardial Contrast Echocardiography Study. Echocardiography, 25: 591-599. doi:10.1111/j.1540-8175.2008.00666.xpt_PT
dc.identifier.issn0742-2822-
dc.identifier.urihttp://hdl.handle.net/10451/34797-
dc.description© 2008, the Authors Journal compilation © 2008, Blackwell Publishing, Inc.pt_PT
dc.description.abstractBackground: Sickle cell disease (SCD) is characterized by obstruction of microvessels leading to ischemia and necrosis. We have aimed to demonstrate whether myocardial contrast echocardiography (MCE) is able to detect myocardial perfusion abnormalities in SCD patients and to assess their relationship with left ventricle (LV) perfusion and systolic function. Methods: A group of 25 patients with SCD and a control group of 19 normal individuals were studied. Using MCE, myocardial perfusion reserve indices (A, β, and A×β) were obtained, before and after hyperemia with dypiridamole. LV function was also analyzed: ejection fraction (EF), index of myocardial performance (IMP), the ratio of transmitral early-diastolic flow velocity E and the pulsed tissue Doppler mitral annular early diastolic velocity Ea (E/Ea) (E/Ea), tissue Doppler mitral annular peak systolic velocity (Sa), and peak systolic strain (S) were obtained. Results: Myocardial velocity (β) and myocardial blood flow (A×β) reserves were lower in the patients than in controls (1.7 ± 0.4 vs. 3.3 ± 0.2, P = 0.000 and 2.1 ± 0.6 vs. 4.1 ± 0.2, P = 0.000, respectively). In SCD patients, a correlation was found between β reserve and EF, IMP, Sa, E/Ea, and S% and between A×β reserve and Sa. Conclusions: MCE detected abnormal perfusion reserve in patients with SCD, which correlated with systolic function indices. This suggests that perfusion plays a role in SCD ventricular dysfunction.pt_PT
dc.description.sponsorshipThis study was supported by the Centro de Cardiologia da Universidade de Lisboa (CCUL) and the Foundation for Science and Technology, an organ of the Portuguese Ministry of Science and Higher Educationpt_PT
dc.language.isoengpt_PT
dc.publisherBlackwell Publishingpt_PT
dc.rightsrestrictedAccesspt_PT
dc.subjectContrast echocardiographypt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectMyocardial perfusionpt_PT
dc.subjectVentricular functionpt_PT
dc.subjectMyocardial contrast echocardiographypt_PT
dc.titleAbnormal myocardial flow reserve in sickle cell disease : a myocardial contrast echocardiography studypt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume25pt_PT
dc.identifier.doi10.1111/j.1540-8175.2008.00666.xpt_PT
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