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Title: The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
Author: Salústio, Paulo
Feio, Gabriel
Figueirinhas, João
Pinto, João
Marques, Helena Cabral
Keywords: Ibuprofen
Physical mixture
Optical microscopy
FT-IR spectroscopy
UV spectroscopy
Issue Date: 17-Oct-2008
Publisher: Elsevier
Citation: Eur J Pharm Biopharm. 2009 Feb; 71(2):377-386
Abstract: The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by bcyclodextrin (bCD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, bCD, and inclusion of either IB or IN in aqueous solutions of bCD. In the latter method water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added to an acidic solution (pH = 2) to quantify the concentration of the drug inside bCD cavity. Other media (pH = 5 and 7) were used to prove the existence of drug not complexed in each powder, as the drugs solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the bCD did not depend neither on the method of complexation nor on the processes of drying considered.
Description: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.
Peer review: yes
ISSN: 0939-6411
Appears in Collections:FF - Artigos em Revistas Internacionais

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