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Title: Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts
Authors: Dias, Catarina
Graça, João Adriano Borralho
Gonçalves, Maria de Lurdes
Keywords: Scilla maderensis Menezes
Positive inotropic effect
Cardiac glycoside-like effect
Madeira Archipelago
Issue Date: 2000
Publisher: Elsevier
Citation: Journal of Ethnopharmacology, 71 (2000) 487–492
Abstract: Scilla maderensis Menezes (Hyacinthaceae) is endemic to the Portuguese Archipelago of Madeira. The taxonomic proximity between Scilla L. and Urginea Steinh. genus, and also the knowledge that bulbs of Urginea maritima (L.) Baker (Scilla maritima L.) contain cardiac glycosides of the bufadienolide type, led us to a phytochemical and pharmacological study of S. maderensis. Extracts obtained from the bulbs were screened by TLC and tested in the isolated frog heart preparation. The TLC screening revealed spots with colours and Rf values similar to those obtained for proscillaridin and scillaren A. In the frog heart preparation the extracts showed a positive inotropic effect and toxic doses induced the arrest of the heartbeat in systole. We can conclude that the bulbs of S. maderensis contain substances exerting pharmacological effects on the heart.
Peer review: yes
ISSN: 0378-8741
Publisher Version:
Appears in Collections:FF-DQFT - Artigos em Revistas Internacionais

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