Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/3846
Título: Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts
Autor: Dias, Catarina
Graça, João Adriano Borralho
Gonçalves, Maria de Lurdes
Palavras-chave: Scilla maderensis Menezes
Hyacinthaceae
Bulbs
Positive inotropic effect
Cardiac glycoside-like effect
Madeira Archipelago
Endemic
Vulnerable
Data: 2000
Editora: Elsevier
Citação: Journal of Ethnopharmacology, 71 (2000) 487–492
Resumo: Scilla maderensis Menezes (Hyacinthaceae) is endemic to the Portuguese Archipelago of Madeira. The taxonomic proximity between Scilla L. and Urginea Steinh. genus, and also the knowledge that bulbs of Urginea maritima (L.) Baker (Scilla maritima L.) contain cardiac glycosides of the bufadienolide type, led us to a phytochemical and pharmacological study of S. maderensis. Extracts obtained from the bulbs were screened by TLC and tested in the isolated frog heart preparation. The TLC screening revealed spots with colours and Rf values similar to those obtained for proscillaridin and scillaren A. In the frog heart preparation the extracts showed a positive inotropic effect and toxic doses induced the arrest of the heartbeat in systole. We can conclude that the bulbs of S. maderensis contain substances exerting pharmacological effects on the heart.
Peer review: yes
URI: http://dx.doi.org/10.1016/S0378-8741(00)00193-8
http://hdl.handle.net/10451/3846
ISSN: 0378-8741
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0378874100001938
Aparece nas colecções:FF - Artigos em Revistas Internacionais

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