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Title: Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3- d]isoxazole-4,9-diones
Author: Santos, Maria M. M.
Faria, Natália
Iley, Jim
Coles, Simon J.
Hursthouse, Michael B.
Martins, M. Luz
Moreira, Rui
Keywords: Quinones
Antifungal agents
Issue Date: 2010
Publisher: Elsevier
Citation: Santos, Maria M. M.; Faria, Natália; Iley, Jim; Coles, Simon J.; Hursthouse, Michael B.; Martins, M. Luz; Moreira, Rui. Reaction of Naphthoquinones with Substituted Nitromethanes. Facile Synthesis and antifungal activity of Naphtho[2,3- d]isoxazole-4,9-diones, Bioorganic and Medicinal Chemistry Letters, 20, 193-195, 2010.
Abstract: We report here a simple entry into naphtho[2,3-d]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.
Peer review: yes
ISSN: 0960-894X
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Appears in Collections:FF - Artigos em Revistas Internacionais

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