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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/3853

Title: Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
Authors: Salústio, Paulo
Marques, Helena Cabral
Costa, Paulo
Pinto, João
Keywords: b-Cyclodextrin
Capsule
Compaction
Dissolution
Ibuprofen
Minitablet
Issue Date: 30-Dec-2010
Publisher: Elsevier
Citation: Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30
Abstract: Mixtures containing ibuprofen (IB) complexed with b-cyclodextrin (bCD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, bCD and IBbCD) were characterized for moisture content, densities (true and bulk), angle of repose and Carr’s index, X-ray and NMR. From physical mixtures and IBbCD complexes without other excipients were prepared 2.5-mm-diameter minitablets and capsules. Minitablets were characterized for the energy of compaction, tensile strength, friability, density and IB release (at pH 1.0 and 7.2), whereby capsules were characterized for IB release. The results from the release of IB were analyzed using different parameters, namely, the similarity factor (f2), the dissolution efficiency (DE) and the amounts released at a certain time (30, 60 and 180 min) and compared statistically (a = 0.05). The release of IB from the minitablets showed no dependency on the amount of water used in the formation of the complexes. Differences were due to the compaction force used or the presence of a shell for the capsules. The differences observed were mostly due to the characteristics of the particles (dependent on the method considered on the formation of the complexes) and neither to the dosage form nor to the complex of the IB.
Description: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30.
Peer Reviewed: yes
URI: http://dx.doi.org/10.1016/j.ejpb.2010.12.022
http://hdl.handle.net/10451/3853
ISSN: 0939-6411
Publisher version: http://www.sciencedirect.com/science/article/pii/S0939641110003632
Appears in Collections:FF-DFGTF - Artigos em Revistas Internacionais

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