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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/3888

Title: 2-(4´-Aminobenzenamine)-pyrimidine, a new alfa-antagonist from Autonoë madeirensis
Authors: Dias, Catarina
Paulo, Alexandra
Nascimento, José
Houghton, Peter
Hawkes, Jane E.
Gonçalves, Maria Lurdes
Issue Date: 2003
Publisher: Georg Thieme Verlag
Citation: Planta Med 2003; 69(11): 1060-1062
Abstract: A new natural pyrimidine derivative, 2-(4´-aminobenzenamine)-pyrimidine (1), was isolated from the bulbs of Autonoë madeirensis, a Hyacinthaceae of Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alfa-1-adrenergic antagonists, we investigated the effect of 1 in the rat vas deferens contractility induced by the alfa-1-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alfa-1-adrenoceptor antagonist and suggest a competitive mechanism of action.
Peer Reviewed: yes
URI: http://dx.doi.org/10.1055/s-2003-45158
ISSN: 0032-0943
Publisher version: https://www.thieme-connect.de/ejournals/abstract/plantamedica/doi/10.1055/s-2003-45158
Appears in Collections:FF-DQFT - Artigos em Revistas Internacionais

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