Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10451/3888
Título: | 2-(4´-Aminobenzenamine)-pyrimidine, a new alfa-antagonist from Autonoë madeirensis |
Outros títulos: | 2-(4´-Aminobenzenamine)-pyrimidine, a new α-antagonist from Autonoë madeirensis |
Autor: | Dias, Catarina Paulo, Alexandra Nascimento, José Houghton, Peter Hawkes, Jane E. Gonçalves, Maria Lurdes |
Data: | 2003 |
Editora: | Georg Thieme Verlag |
Citação: | Planta Med 2003; 69(11): 1060-1062 |
Resumo: | A new natural pyrimidine derivative, 2-(4´-aminobenzenamine)-pyrimidine (1), was isolated from the bulbs of Autonoë madeirensis, a Hyacinthaceae of Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alfa-1-adrenergic antagonists, we investigated the effect of 1 in the rat vas deferens contractility induced by the alfa-1-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alfa-1-adrenoceptor antagonist and suggest a competitive mechanism of action. |
Peer review: | yes |
URI: | http://dx.doi.org/10.1055/s-2003-45158 http://hdl.handle.net/10451/3888 |
ISSN: | 0032-0943 |
Versão do Editor: | https://www.thieme-connect.de/ejournals/abstract/plantamedica/doi/10.1055/s-2003-45158 |
Aparece nas colecções: | FF - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Dias_Catarina_2003_PlantaMedica.pdf | 76,48 kB | Adobe PDF | Ver/Abrir Acesso Restrito. Solicitar cópia ao autor! |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.