Universidade de Lisboa Repositório da Universidade de Lisboa

Repositório da Universidade de Lisboa >
Faculdade de Farmácia (FF) >
Departamento de Química Farmacêutica e Terapêutica (FF-DQFT) >
FF-DQFT - Artigos em Revistas Internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/3936

Título: Antimicrobial properties of Plectranthus ornatus extracts, 11-acetoxyhalima-5,13-dien-15-oic acid metabolite and its derivatives
Autor: Rijo, Patrícia
Rodríguez, Benjamín
Duarte, Aida
Simões, M. Fátima
Palavras-chave: 11R*-Acetoxyhalima-5,13E-dien-15-oic acid
Antimicrobial activity
Diterpenes
Labiatae
Plectranthus ornatus extracts
Issue Date: 2011
Editora: Bentham Science Publishers
Citação: The Natural Products Journal, 2011, 1(1), 57-64
Resumo: An antimicrobial screening of six different extracts of Plectranthus ornatus, revealed anti-Gram positive bacteria activity for the acetone and methanol-water extracts. 11R*-Acetoxyhalima-5,13E-dien-15-oic acid (1), isolated from the acetone extract of P. ornatus, exhibited growth inhibitory activity against five Staphylococcus and five Enterococcus strains. [MIC values 15.62 μg/mL (43.15 μM) – 62.50 μg/mL (172.65 μM)]. Diterpenes with a halimane skeleton are rarely isolated and their pharmacologic properties remain unknown. To study the potential of 1 as antibacterial prototype some derivatives (2-10) were obtained from 1 and the majority were tested against the same ten Gram positive bacteria. The more active was the (11R*,13E)-halima-5,13-diene-11,15-diol (4) with MIC values of 15.62 μg/mL (51.05 μM) to 31.25 μg/mL (102.12 μM). The preparation and spectroscopic data of 2 – 10 are also reported.
Arbitragem científica: yes
URI: http://dx.doi.org/10.2174/2210316311101010057
http://hdl.handle.net/10451/3936
ISSN: 2210-3163
Versão do Editor: http://www.benthamdirect.org/pages/content.php?NPJ/2011/00000001/00000001/0007NPJ.SGM
Appears in Collections:FF-DQFT - Artigos em Revistas Internacionais

Files in This Item:

File Description SizeFormat
Nat_Prod_J_2011_1_57_64.pdf917,32 kBAdobe PDFView/Open
Restrict Access. You can request a copy!
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

  © Universidade de Lisboa / SIBUL
Alameda da Universidade | Cidade Universitária | 1649-004 Lisboa | Portugal
Tel. +351 217967624 | Fax +351 217933624 | repositorio@reitoria.ul.pt - Feedback - Statistics
DeGóis
  Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE