Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/4360
Título: Modulation and metamodulation of synapses by adenosine
Autor: Ribeiro, J. A.
Sebastião, A. M.
Palavras-chave: Adenosine
Metamodulation
Modulation
Synapses
Data: 2010
Editora: Wiley-Blackwell
Relatório da Série N.º: Vol. 199; nº 2
Resumo: The presence of adenosine in all nervous system cells (neurones and glia) together with its intensive release following insults makes adenosine as a sort of ‘regulator’ of synaptic communication, leading to the homeostatic coordination of brain function. Besides the direct actions of adenosine on the neurosecretory mechanisms, to tune neurotransmitter release, adenosine receptors interact with other receptors as well as with transporters as part of its attempt to fine-tune synaptic transmission. This review will focus on examples of the different ways adenosine can use to modulate or metamodulate synapses, in other words, to trigger or brake the action of some neurotransmitters and neuromodulators, to cross-talk with other G proteincoupled receptors, with ionotropic receptors and with receptor kinases as well as with transporters. Most of these interactions occur through A2A receptors, which in spite of their low density in some brain areas, such as the hippocampus, may function as amplifiers of the signalling of other mediators at synapses.
Peer review: yes
URI: http://hdl.handle.net/10451/4360
http://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2010.02115.x/full
ISSN: 1748-1716
Aparece nas colecções:FM-IFN-Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Junho_2010.pdf262,06 kBAdobe PDFVer/Abrir    Acesso Restrito. Solicitar cópia ao autor!


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.