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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/4851

Title: Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis
Authors: Gomes, João P.
Borrego, Maria J.
Atik, Berna
Santo, Irene
Azevedo, Jacinta
Brito de Sá, Armando
Nogueira, Paulo
Dean, Deborah
Keywords: Chlamydia trachomatis
Patogénese
Doenças sexualmente transmissíveis
Doenças infecciosas
Issue Date: 2006
Publisher: Institut Pasteur
Citation: Microbes and Infection 8 (2006):16–26
Abstract: The association of infectious burden of Chlamydia trachomatis with patient characteristics and clinical disease may have implications for understanding disease pathogenesis.We examined chlamydial load from 171 urine samples where load was based on copy number of organisms per copy number of eukaryotic cells derived by real-time quantitative PCR. High- (E, F, G) and low-prevalence (Ia, H, J, Ja) genotypes in the population had similar loads, suggesting a similar propensity for replicating in vivo, despite their differential ecological success. Symptomatic and asymptomatic patients also had similar chlamydial loads, indicating that virulence differences are likely not associated with variations in replication. There was a significant difference in genotypes by age for F (< 31 years; P = 0.031) and for H where the mean age was lower than for the most prevalent genotype, E (P = 0.013). Also, men had a significantly lower load than women when the genotype was F (P = 0.042), although there was no significant difference in load between partners. Patients with recurrent chlamydial infections had a significant reduction in load with each subsequent episode regardless of genotype (P = 0.007), suggesting that immune defenses do not block chlamydial entry but may impact replication. Additionally, the probability of being infected with J was 7.7-fold higher in patients with prior chlamydial infections (P = 0.016), and although the loads were lower when compared with patients without prior infection, the results did not reach statistical significance. These findings suggest that chlamydial burden could be an important marker for recurrence and host immune response, which would facilitate pathogenesis research.
Peer Reviewed: yes
URI: http://hdl.handle.net/10451/4851
http://dx.doi.org/10.1016/j.micinf.2005.05.014
ISSN: 1286-4579
Publisher version: Pode ter acesso à versão integral deste artigo através do portal www.b-on.pt. Isto no caso de efectuar a pesquisa a partir de um IP de um Campus Universitário ou ligado a este através de uma ligação remota tipo VPN ou outra, utilizando este link: http://www.sciencedirect.com/science/article/pii/S1286457905002029
Appears in Collections:FM-IMP-Artigos em Revistas Internacionais

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