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Title: Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in Portugal after 7 years of heptavalent conjugate vaccine use
Authors: Aguiara, Sandra I.
Brito, Maria J.
Gonçalo-Marques, José
Melo-Cristino, José
Ramirez, Mário
Keywords: Streptococcus pneumoniae
Conjugate vaccines
Antimicrobial resistance
Issue Date: 19-Jul-2010
Publisher: Elsevier
Citation: Vaccine 28 (2010) 5167–5173
Abstract: We characterized 353 isolates responsible for pediatric invasive pneumococcal infections (IPD) in Portugal between 2006 and 2008. Serotypes included in the seven-valent conjugate vaccine (PCV7) accounted for 17% of IPD. Serotypes 1, 7F and 19A were the most frequent causes of IPD and the later consolidated as the most frequent serotype among erythromycin and penicillin non-susceptible isolates. Serotype 1 was associated with older children and empyemas, while serotype 19A was associated with IPD in younger (<2 years) children. The higher valency vaccines PCV10 and PCV13 have a potentially superior coverage, 55% and 83% respectively, but non-vaccine serotypes are emerging as important causes of IPD. A decline of resistance with patient age was noted. Comparing with previous data from Portugal, this study showed a continued decline of PCV7 serotypes and that overall resistance has stabilized following the initial decline of the first post-PCV7 years.
Description: © 2010 Elsevier Ltd. All rights reserved.
Peer review: yes
ISSN: 0264-410X
Appears in Collections:IMM - Artigos em Revistas Internacionais

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