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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/5870

Título: Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
Autor: Cascão, Rita
Moura, Rita A.
Perpétuo, Inês
Canhão, Helena
Vieira-Sousa, Elsa
Mourão, Ana F.
Rodrigues, Ana M.
Polido-Pereira, Joaquim
Queiroz, Mário V.
Rosário, Henrique S.
Souto-Carneiro, Maria M.
Graça, Luís
Fonseca, João E.
Palavras-chave: Cytokines
Neutrophils
Th17 cells
Rheumatoid arthritis
Chronic inflammatory autoimmune disease
Issue Date: 2010
Editora: BioMed Central
Citação: Arthritis Research & Therapy 2010, 12:R196
Resumo: Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and perpetuation of this disease. The main goal of this work was to determine whether cytokines driving neutrophil and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease duration and before treatment (VERA). Methods: Cytokines related to neutrophil and Th17 activation were quantified in the serum of VERA and established RA patients and compared with other very early arthritis (VEA) and healthy controls. Synovial fluid (SF) from RA and osteoarthritis (OA) patients was also analyzed. Results: VERA patients had increased serum levels of cytokines promoting Th17 polarization (IL-1b and IL-6), as well as IL-8 and Th17-derived cytokines (IL-17A and IL-22) known to induce neutrophil-mediated inflammation. In established RA this pattern is more evident within the SF. Early treatment with methotrexate or corticosteroids led to clinical improvement but without an impact on the cytokine pattern. Conclusions: VERA patients already display increased levels of cytokines related with Th17 polarization and neutrophil recruitment and activation, a dysregulation also found in SF of established RA. 0 Thus, our data suggest that a cytokine-milieu favoring Th17 and neutrophil activity is an early event in RA pathogenesis.
Descrição: © 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Arbitragem científica: yes
URI: http://hdl.handle.net/10451/5870
doi:10.1186/ar3168
http://arthritis-research.com/content/pdf/ar3168.pdf
ISSN: 1478-6354
Appears in Collections:IMM - Artigos em Revistas Internacionais

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