Universidade de Lisboa Repositório da Universidade de Lisboa

Repositório da Universidade de Lisboa >
Instituto de Medicina Molecular (IMM) >
IMM - Artigos em Revistas Internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/5992

Título: Alterations on peripheral blood B-cell subpopulations in very early arthritis patients
Autor: Moura, Rita A.
Weinmann, Pamela
Pereira, Patrícia A.
Caetano-Lopes, Joana
Canhão, Helena
Sousa, Elsa
Mourão, Ana F.
Rodrigues, Ana M.
Queiroz, Mário V.
Souto-Carneiro, Maria M.
Graça, Luís
Fonseca, João E.
Palavras-chave: Rheumatoid arthritis
B cells
Issue Date: 7-Mar-2010
Editora: Oxford University Press
Citação: Rheumatology 2010;49:1082–1092
Resumo: Objective. To characterize circulating B-cell subpopulations of arthritis patients with <6 weeks of disease duration. Methods. Peripheral blood samples were collected from very early untreated polyarthritis patients, with <6 weeks of disease duration, for flow cytometric evaluation of B-cell subpopulations. Samples from patients who were later diagnosed as RA [very early RA (VERA)] were also collected 4–6 weeks after starting a low dose of prednisone (5–10 mg) and 4 months after reaching the minimum effective dose of MTX. A matched healthy group was used as a control. Results. VERA patients have a lower percentage of total peripheral blood memory B cells (CD19+CD27+) and a significant decrease in the frequency of circulating pre-switch memory B cells (CD19+IgD+CD27+) as compared with controls. Therapy with corticosteroids or MTX was unable to restore the normal frequencies of these B-cell subpopulations. A significant decrease in peripheral pre-switch memory B cells is equally observed in other early arthritis patients. Furthermore, no significant differences are found in the frequencies of CD4+ and CD8+ T cells in all patient groups. Conclusions. In very early polyarthritis patients, there is a reduction in circulating pre-switch memory B cells. The reasons that may account for this effect are still unknown. Short-term corticosteroids and MTX do not seem to have a direct effect on circulating B-cell subpopulations in VERA patients.
Descrição: ©The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Arbitragem científica: yes
URI: http://hdl.handle.net/10451/5992
ISSN: 1462-0324
Appears in Collections:IMM - Artigos em Revistas Internacionais

Files in This Item:

File Description SizeFormat
1_LG.pdf573,62 kBAdobe PDFView/Open
Restrict Access. You can request a copy!

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


  © Universidade de Lisboa / SIBUL
Alameda da Universidade | Cidade Universitária | 1649-004 Lisboa | Portugal
Tel. +351 217967624 | Fax +351 217933624 | repositorio@reitoria.ul.pt - Feedback - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia