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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/6052

Título: Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival
Autor: Moura, Rita A.
Cascão, Rita
Perpétuo, Inês
Canhão, Helena
Vieira-Sousa, Elsa
Mourão, Ana F.
Rodrigues, Ana M.
Polido-Pereira, Joaquim
Queiroz, Mário V.
Rosário, Henrique S.
Souto-Carneiro, Maria M.
Graça, Luís
Fonseca, João E.
Palavras-chave: B cells
VERA
Synovial fluid
APRIL
BAFF
Issue Date: Feb-2011
Editora: Oxford University Press
Citação: Rheumatology 2011;50:278–282
Resumo: OBJECTIVES: B cells play an important role in the perpetuation of RA, particularly as autoantibody-producing cells. The ICs that further develop deposit in the joints and aggravate the inflammatory process. However, B-cell contribution in the very early stage of the disease remains unknown. The main goal of this work was to determine the concentration of cytokines potentially relevant for B-cell activation in serum from very early polyarthritis patients, with <6 weeks of disease duration, who latter on evolved into very early RA (VERA). METHODS: A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF) and IL-21 levels were measured by ELISA in the serum of VERA, other very early arthritis (VEA), established RA patients and controls. SF samples of established RA were also analysed. RESULTS: VERA patients have higher levels of APRIL and BAFF as compared with VEA, established RA and controls. Furthermore, APRIL and BAFF levels are also significantly elevated in RA-SF when compared with serum. CONCLUSIONS: The increased levels of APRIL and BAFF in VERA patients suggests that B-cell activation and the development of autoreactive B-cell responses might be crucial in early phases of RA. Therefore, APRIL and BAFF could be promising targets for therapy in the early phase of RA.
Descrição: ©Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Arbitragem científica: yes
URI: http://hdl.handle.net/10451/6052
doi:10.1093/rheumatology/keq338
ISSN: 1462-0324
Appears in Collections:IMM - Artigos em Revistas Internacionais

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