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|Title: ||Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival|
|Authors: ||Moura, Rita A.|
Mourão, Ana F.
Rodrigues, Ana M.
Queiroz, Mário V.
Rosário, Henrique S.
Souto-Carneiro, Maria M.
Fonseca, João E.
|Keywords: ||B cells|
|Issue Date: ||Feb-2011|
|Publisher: ||Oxford University Press|
|Citation: ||Rheumatology 2011;50:278–282|
|Abstract: ||OBJECTIVES: B cells play an important role in the perpetuation of RA, particularly as autoantibody-producing cells. The ICs that further develop deposit in the joints and aggravate the inflammatory process. However, B-cell contribution in the very early stage of the disease remains unknown. The main goal of this work was to determine the concentration of cytokines potentially relevant for B-cell activation in serum from very early polyarthritis patients, with <6 weeks of disease duration, who latter on evolved into very early RA (VERA).
METHODS: A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF) and IL-21 levels were measured by ELISA in the serum of VERA, other very early arthritis (VEA), established RA patients and controls. SF samples of established RA were also analysed.
RESULTS: VERA patients have higher levels of APRIL and BAFF as compared with VEA, established RA and controls. Furthermore, APRIL and BAFF levels are also significantly elevated in RA-SF when compared with serum.
CONCLUSIONS: The increased levels of APRIL and BAFF in VERA patients suggests that B-cell activation and the development of autoreactive B-cell responses might be crucial in early phases of RA. Therefore, APRIL and BAFF could be promising targets for therapy in the early phase of RA.|
|Description: ||©Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.|
|Peer Reviewed: ||yes|
|Appears in Collections:||IMM - Artigos em Revistas Internacionais|
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