Universidade de Lisboa Repositório da Universidade de Lisboa

Repositório da Universidade de Lisboa >
Instituto de Medicina Molecular (IMM) >
IMM - Artigos em Revistas Internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/6054

Título: Mechanisms of tolerance and allergic sensitization in the airways and the lungs
Autor: Curotto de Lafaille, Maria A.
Lafaille, Juan J.
Graça, Luís
Palavras-chave: Respiratory mMucosa
T-lymphocytes, regulatory
Issue Date: Oct-2010
Editora: Elsevier
Citação: Current Opinion in Immunology 2010, 22:616–622
Resumo: The respiratory mucosa is constantly exposed to non-infectious substances that have the potential of triggering inflammation. While many particles are excluded, soluble molecules can reach the epithelium surface, where they can be uptaken by dendritic cells and stimulate an adaptive immune response. Most mucosal responses result in tolerance to subsequent antigen encounters, which is mediated by Foxp3(+) regulatory T cells. Genetic and environmental factors, added to the ability of certain allergens to induce innate responses, can predispose to allergic sensitization. In this review we discuss recent advances in the understanding of the mechanisms of tolerance and allergic sensitization to airborne allergens.
Descrição: © 2010 Elsevier Ltd. All rights reserved
Arbitragem científica: yes
URI: http://hdl.handle.net/10451/6054
DOI 10.1016/j.coi.2010.08.014
ISSN: 0952-7915
Appears in Collections:IMM - Artigos em Revistas Internacionais

Files in This Item:

File Description SizeFormat
6_LG_2010.pdf161,78 kBAdobe PDFView/Open
Restrict Access. You can request a copy!

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


  © Universidade de Lisboa / SIBUL
Alameda da Universidade | Cidade Universitária | 1649-004 Lisboa | Portugal
Tel. +351 217967624 | Fax +351 217933624 | repositorio@reitoria.ul.pt - Feedback - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia