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Title: Targeting γδ T lymphocytes for cancer immunotherapy : from novel mechanistic insight to clinical application
Authors: Gomes, Anita Q.
Martins, Duarte S.
Silva-Santos, Bruno
Keywords: T lymphocytes
Cancer immunotherapy
Interferon gama
Issue Date: 15-Dec-2010
Publisher: American Association for Cancer Research
Citation: Cancer Res; 70(24) December 15, 2010
Abstract: Abundant interferon-γ secretion, potent cytotoxicity, and major histocompatibility complex–independent targeting of a large spectrum of tumors make γδ T cells attractive mediators of cancer immunotherapy. However, a better understanding of the molecular mechanisms involved in tumor cell recognition and γδ T-cell activation is required to improve the limited success of gd T-cell–mediated treatments. Here, we review key advances in basic knowledge made over the past 3 years, and summarize the results of γδ T-cell–based clinical trials concluded to date. We also highlight new research directions on the basis of the modulation of receptors that control the function of γδ T cells.
Description: © 2010 American Association for Cancer Research
Peer review: yes
ISSN: 0008-5472
Appears in Collections:IMM - Artigos em Revistas Internacionais

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