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Title: Cutting Edge : adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γβ T cells upon infection
Author: Ribot, Julie C.
Chaves-Ferreira, Miguel
d'Orey, Francisco
Wencker, Mélanie
Gonçalves-Sousa, Natacha
Decalf, Jérémie
Simas, João P.
Hayday, Adrian C.
Silva-Santos, Bruno
Keywords: T lymphocytes
Antigens, CD27
Genes, T-cell receptor
Issue Date: Oct-2010
Publisher: American Association of Immunologists
Citation: The Journal of Immunology, 2010, 185: 6421–6425
Abstract: γβ T lymphocytes are commonly viewed as embracing properties of both adaptive and innate immunity. Contributing to this is their responsiveness to pathogen products, either with or without the involvement of the TCR and its coreceptors. This study clarifies this paradoxical behavior by showing that these two modes of responsiveness are the properties of two discrete sets of murine lymphoid γβ T cells. Thus, MyD88 deficiency severely impaired the response to malaria infection of CD27(-), IL-17A–producing γβ T cells, but not of IFN-γ–producing γβ cells. Instead, the latter compartment was severely contracted by ablating CD27, which synergizes with TCRγβ in the induction of antiapoptotic mediators and cell cycle-promoting genes in CD27(+), IFN-γ–secreting γβ T cells. Hence, innate versus adaptive receptors differentially control the peripheral pool sizes of discrete proinflammatory γβ T cell subsets during immune responses to infection.
Description: ©2010 by The American Association of Immunologists, Inc. All rights reserved.
Peer review: yes
ISSN: 0022-1767
Appears in Collections:IMM - Artigos em Revistas Internacionais

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