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Title: Caffeine, adenosine receptors, and synaptic plasticity
Authors: Costenla, Ana Rita
Cunha, Rodrigo A.
Mendonça, Alexandre de
Keywords: A2A receptors
Long-term potentiation
Synaptic plasticity
Issue Date: 2010
Publisher: IOS Press
Citation: Journal of Alzheimer’s Disease 20 (2010) S25–S34
Abstract: Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordingly, rats drinking caffeine (1 g/L) for 3 weeks, displayed a concentration of caffeine of circa 22 μM in the hippocampus. It is known that selective adenosine A1 receptor antagonists facilitate, whereas selective adenosine A2A receptor antagonists attenuate, long term potentiation (LTP) in the hippocampus. Although caffeine is a non-selective antagonist of adenosine receptors, it attenuates frequency-induced LTP in hippocampal slices in a manner similar to selective adenosine A2A receptor antagonists. These effects of low micromolar concentration of caffeine (30 μM) are maintained in aged animals, which is important when a possible beneficial effect for caffeine in age-related cognitive decline is proposed. Future studies will still be required to confirm and detail the involvement of A1 and A2A receptors in the effects of caffeine on hippocampal synaptic plasticity, using both pharmacological and genetic approaches.
Description: Copyright ©2012 IOS Press All rights reserved.
Peer review: yes
DOI 10.3233/JAD-2010-091384
ISSN: 1387-2877
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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