Universidade de Lisboa Repositório da Universidade de Lisboa

Repositório da Universidade de Lisboa >
Instituto de Medicina Molecular (IMM) >
IMM - Artigos em Revistas Internacionais >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/6253

Title: Caffeine, adenosine receptors, and synaptic plasticity
Authors: Costenla, Ana Rita
Cunha, Rodrigo A.
Mendonça, Alexandre de
Keywords: A2A receptors
Adenosine
Caffeine
Long-term potentiation
Hippocampus
Synaptic plasticity
Issue Date: 2010
Publisher: IOS Press
Citation: Journal of Alzheimer’s Disease 20 (2010) S25–S34
Abstract: Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordingly, rats drinking caffeine (1 g/L) for 3 weeks, displayed a concentration of caffeine of circa 22 μM in the hippocampus. It is known that selective adenosine A1 receptor antagonists facilitate, whereas selective adenosine A2A receptor antagonists attenuate, long term potentiation (LTP) in the hippocampus. Although caffeine is a non-selective antagonist of adenosine receptors, it attenuates frequency-induced LTP in hippocampal slices in a manner similar to selective adenosine A2A receptor antagonists. These effects of low micromolar concentration of caffeine (30 μM) are maintained in aged animals, which is important when a possible beneficial effect for caffeine in age-related cognitive decline is proposed. Future studies will still be required to confirm and detail the involvement of A1 and A2A receptors in the effects of caffeine on hippocampal synaptic plasticity, using both pharmacological and genetic approaches.
Description: Copyright ©2012 IOS Press All rights reserved.
Peer Reviewed: yes
URI: http://hdl.handle.net/10451/6253
http://iospress.metapress.com/content/77r8428t6g2j81pl/fulltext.pdf
DOI 10.3233/JAD-2010-091384
ISSN: 1387-2877
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

Files in This Item:

File Description SizeFormat
Artigo.pdf557.04 kBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

  © Universidade de Lisboa / SIBUL
Alameda da Universidade | Cidade Universitária | 1649-004 Lisboa | Portugal
Tel. +351 217967624 | Fax +351 217933624 | repositorio@reitoria.ul.pt - Feedback - Statistics
DeGóis
  Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE