Please use this identifier to cite or link to this item:
Title: Adenosine and related drugs in brain diseases: present and future in clinical trials
Author: Lopes, Luísa V.
Sebastião, Ana M.
Ribeiro, Joaquim A.
Keywords: Adenosine
Clinical trials
Drug addiction
Issue Date: 2011
Publisher: Bentham Science Publishers
Citation: Current Topics in Medicinal Chemistry, 2011, 11, 1087-1101
Abstract: Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a metabolic intermediate. Besides its metabolic role within the cells, adenosine is released into the extracellular space either by neurons or astrocytes acting as a neuromodulator. Extracellular adenosine exerts its action by activating multiple G-protein coupled receptors (subtypes A1, A2A, A2B and A3) having a wide range of physiological effects in the brain. Adenosine levels rise markedly in response to chemia,hypoxia,excitotoxicity or inflammation being a neuroprotectant under these conditions.However, adenosine may also contribute to neuronal damage and cell death in other circumstances. These actions are firmly established using multiple animal models. Therefore, increasing attention is now given to the role of adenosine in human brain function and its potential benefit for clinical applications. This review covers recent studies undertaken mostly in humans revealing the actions of adenosine and related drugs in cognition and memory as well as in various pathological situations such as psychiatric disorders, drug addiction and neurodegenerative disorders. The actual use of adenosine or adenosine receptor ligands in ongoing clinical trials for the treatment of schizophrenia, panic disorder and anxiety, cocaine dependence and Parkinson’s disease is discussed. The evidence herein reviewed highlights the promising potential of adenosine or adenosine receptor ligands as therapeutic agents in several brain disorders.
Description: © 2011 Bentham Science Publishers Ltd.
Peer review: yes
ISSN: 1568-0266
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
Luisa_Lopes_02.pdf357,84 kBAdobe PDFView/Open    Request a copy

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.