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Title: Laser-light scattering approach to peptide–membrane interaction
Authors: Domingues, Marco M.
Santos, Nuno C.
Keywords: Peptides
Membrane lipids
Membrane proteins
Membranes (Biology)
Peptide drugs
Protein binding
Issue Date: 2010
Publisher: International University Line
Abstract: Membrane-active peptides are becoming widely used, mainly due to their high therapeutic potential. Although the therapeutic action is characterized, the mechanisms of interaction are often unclear or controversial. In biophysical studies, non-invasive techniques are overlooked when studying the effect of peptides on membranes. Light scattering techniques, such as dynamic light scattering and static light scattering, can be used as tools to determine whether promotion of membrane aggregation in the presence of peptides and of self-peptide aggregation in solution occurs. More recently, light scattering has been used for evaluating the alteration on membrane surface charge (ζ-potential) promoted by membrane–peptide interactions. The data obtained by these techniques (either by themselves or combined with complementary experimental approaches) therefore yield valuable elucidations of membrane-active peptides’ mechanisms of action at the molecular level.
Description: © International University Line, 2010
ISBN: 978-0-9720774-5-3
Appears in Collections:IMM - Livros e Capítulos de livros

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