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Title: Proteomics at the interface of psychology, gut physiology and dysfunction: an underexploited approach that deserves expansion
Authors: Lopes, Luísa V.
Kussmann, Martin
Keywords: Biomarker
Gut–brain axis
Issue Date: 2011
Publisher: Expert Reviews
Citation: Expert Rev. Proteomics 8(5), 605–614 (2011)
Abstract: Gut functions such as digestion and absorption are essential to life and the emerging insights into the gut–brain axis – that is,the cross talk between the enteric and CNS – point towards critical links between(eating)behavior,psychology,whole body and gut physiology,and digestive and overall health.While proteomics is ideally positioned to shed more light on these interactions,be it applied to the periphery (e.g.,blood)or the locus of action (i.e., the gut),it is to date largely underexploited, mainly because of challenging sampling and tissue complexity. In view of the contrast between potential and current delivery of proteomics in the context of intestinal health,this article briefs the reader on the state-of-the-art of molecular intestinal research, reviews current proteomic studies (explicitly focusing on the most recent ones that target inflammatory bowel disease patient samples) and argues for an expansion of this research field.
Description: © 2011 Expert Reviews Ltd
Peer review: yes
ISSN: 1478-9450
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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