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Title: EphB–ephrin-B2 interactions are required for thymus migration during organogenesis
Authors: Foster, Katie E.
Gordon, Julie
Cardenas, Kim
Veiga-Fernandes, Henrique
Makinen, Taija
Grigorieva, Elena
Wilkinson, David G.
Blackburn, C. Clare
Richie, Ellen
Manley, Nancy R.
Adams, Ralf H.
Kioussis, Dimitris
Coles, Mark C.
Keywords: Collective cell migration
Thymus organogenesis
Eph receptor
Neural crest
Issue Date: 2010
Publisher: National Academy of Sciences
Citation: PNAS July 27, 2010 vol. 107 no. 30 13414-13419
Abstract: Thymus organogenesis requires coordinated interactions of multiple cell types, including neural crest (NC) cells, to orchestrate the formation, separation, and subsequent migration of the developing thymus from the third pharyngeal pouch to the thoracic cavity. The molecular mechanisms driving these processes are unclear; however, NC-derived mesenchyme has been shown to play an important role. Here, we show that, in the absence of ephrin-B2 expression on thymic NC-derived mesenchyme, the thymus remains in the cervical area instead of migrating into the thoracic cavity. Analysis of individual NC-derived thymic mesenchymal cells shows that, in the absence of ephrin-B2, their motility is impaired as a result of defective EphB receptor signaling. This implies a NC-derived cell-specific role of EphB–ephrin-B2 interactions in the collective migration of the thymic rudiment during organogenesis.
Description: © National Academy of Sciences
Peer review: yes
ISSN: 00278424
Appears in Collections:IMM - Artigos em Revistas Internacionais

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