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Title: The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
Authors: Gascoyne, Duncan M.
Long, Elaine
Veiga-Fernandes, Henrique
de Boer, Jasper
Williams, Owen
Seddon, Benedict
Coles, Mark
Kioussis, Dimitris
Brady, Hugh J. M.
Issue Date: 5-Oct-2009
Publisher: Nature Publishing Group
Citation: Nature Immunology 10, 1118 - 1124 (2009)
Abstract: Natural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and modification of adaptive immune responses. In contrast to commitment to the T cell or B cell lineage, little is known about NK cell lineage commitment. Here we show that the basic leucine zipper (bZIP) transcription factor E4BP4 (also called NFIL3) is essential for generation of the NK cell lineage. E4BP4-deficient mice (Nfil3–/–; called ‘E4bp4–/–’ here) had B cells, T cells and NKT cells but specifically lack NK cells and showed severely impaired NK cell–mediated cytotoxicity. Overexpression of E4bp4 was sufficient to increase NK cell production from hematopoietic progenitor cells. E4BP4 acted in a cell-intrinsic manner ‘downstream’ of the interleukin 15 receptor (IL-15R) and through the transcription factor Id2. E4bp4–/– mice may provide a model for definitive analysis of the contribution of NK cells to immune responses and pathologies.
Description: © 2009 Nature America, Inc. All rights reserved.
There is an Erratum (June 2010) included in this article
Peer review: yes
ISSN: 1529-2908
Appears in Collections:IMM - Artigos em Revistas Internacionais

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