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|Title:||Anticancer peptide SVS-1: efficacy precedes membrane neutralization|
Veiga, Ana Salomé
Schneider, Joel P.
Castanho, Miguel A. R. B.
|Publisher:||American Chemical Society|
|Citation:||Biochemistry 2012, 51, 6263−6265|
|Abstract:||Anticancer peptides are polycationic amphiphiles capable of preferentially killing a wide spectrum of cancer cells relative to noncancerous cells. Their primary mode of action is an interaction with the cell membrane and subsequent activation of lytic effects; however, the exact mechanism responsible for this mode of action remains controversial. Using zeta potential analyses we demonstrate the interaction of a small anticancer peptide with membrane model systems and cancer cells. Electrostatic interactions have a pivotal role in the cell killing process, and in contrast to the antimicrobial peptides action cell death occurs without achieving full neutralization of the membrane charge.|
|Description:||© 2012 American Chemical Society - The final version of record is available at http://pubs.acs.org/journal/bichaw|
|Appears in Collections:||IMM - Artigos em Revistas Internacionais|
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