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Title: Anticancer peptide SVS-1: efficacy precedes membrane neutralization
Authors: Gaspar, Diana
Veiga, Ana Salomé
Sinthuvanich, Chomdao
Schneider, Joel P.
Castanho, Miguel A. R. B.
Issue Date: 2012
Publisher: American Chemical Society
Citation: Biochemistry 2012, 51, 6263−6265
Abstract: Anticancer peptides are polycationic amphiphiles capable of preferentially killing a wide spectrum of cancer cells relative to noncancerous cells. Their primary mode of action is an interaction with the cell membrane and subsequent activation of lytic effects; however, the exact mechanism responsible for this mode of action remains controversial. Using zeta potential analyses we demonstrate the interaction of a small anticancer peptide with membrane model systems and cancer cells. Electrostatic interactions have a pivotal role in the cell killing process, and in contrast to the antimicrobial peptides action cell death occurs without achieving full neutralization of the membrane charge.
Description: © 2012 American Chemical Society - The final version of record is available at
Peer review: yes
URI: hhtp://
ISSN: 0006-2960
Appears in Collections:IMM - Artigos em Revistas Internacionais

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