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Please use this identifier to cite or link to this item: http://hdl.handle.net/10451/7322

Título: What can light scattering spectroscopy do for membrane-active peptide studies?
Autor: Domingues, Marco M.
Santiago, Patrícia S.
Castanho, Miguel A. R. B.
Santos, Nuno C.
Palavras-chave: Dynamic light scattering
Static light scattering
Therapeutic peptides
Issue Date: 2008
Editora: John Wiley and Sons
Citação: J. Pept. Sci. 2008; 14: 394–400
Resumo: Highly charged peptides are important components of the immune system and belong to an important family of antibiotics. Although their therapeutic activity is known, most of the molecular level mechanisms are controversial. A wide variety of different approaches are usually applied to understand their mechanisms, but light scattering techniques are frequently overlooked. Yet, light scattering is a noninvasive technique that allows insights both on the peptide mechanism of action as well as on the development of new antibiotics. Dynamic light scattering (DLS) and static light scattering (SLS) are used to measure the aggregation process of lipid vesicles upon addition of peptides and molecular properties (shape, molecular weight). The high charge of these peptides allows electrostatic attraction toward charged lipid vesicles, which is studied by zeta potential (ζ -potential) measurements.
Descrição: Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
Arbitragem científica: yes
URI: hhtp://dx.doi.org/10.1002/psc.1007
ISSN: 1075-2617
Versão do Editor: The definitive version is available at www3.interscience.wiley.com
Appears in Collections:IMM - Artigos em Revistas Internacionais

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