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Title: Adenosine A2A receptor interactions with receptors for other neurotransmitters and neuromodulators
Author: Ribeiro, J. Alexandre
Keywords: Adenosine
Adenosine A2A receptor
Receptor interaction
CGRP (calcitonin gene related peptide)
VIP (vasoactive intestinal peptide)
Glutamate receptor
Issue Date: 1999
Publisher: Elsevier
Citation: European Journal of Pharmacology 375 (1999) 101–113
Abstract: Adenosine, by activating adenosine A2A receptors, seems to have a crucial function in regulating the activation of multiple receptors that affect neurotransmitter release and/or synaptic transmission, in particular receptors for neuropeptides (calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP)), and NMDA receptors, metabotropic glutamate receptors, nicotinic autofacilitatory receptors, dopamine receptors and adenosine A1 receptors. The manner in which these A2A receptors are involved in interactions with the receptors for other neurotransmitters and or neuromodulators opens novel avenues for the action of this `omnipresent' nucleoside. Either by direct receptor–receptor modulation or by post-receptor mechanisms, adenosine, in its `obsession' to protect cells from insults, uses as many receptor systems as possible to synchronize synaptic transmission, in order to exert what seems to be the `destiny' of this nucleoside—protection of the nervous system.
Description: © 1999 Elsevier Science B.V. All rights reserved.
Peer review: yes
ISSN: 0014-2999
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais

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