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Title: ATP as a presynaptic modulator
Author: Cunha, Rodrigo A.
Ribeiro, J. A.
Keywords: ATP
P2 receptors
Neurotransmitter release
Nerve terminals
Issue Date: 2000
Publisher: Elsevier
Citation: Life Sciences 68 (2000) 119–137
Abstract: There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy, the observations that ATP is released from stimulated central nervous system (CNS) nerve terminals and that responses to exogenously added ATP can be recorded in central neurons, lead to the proposal that ATP might also be a fast transmitter in the CNS. However, in spite of the robust expression of P2 receptor mRNA and binding to P2 receptors in the CNS, the demonstration of central purinergic transmission has mostly remained elusive. We now review evidence to suggest that ATP may also act presynaptically rather than solely postsynaptically in the nervous system.
Description: © 2000 Elsevier Science Inc.
Peer review: yes
ISSN: 0024-3205
Appears in Collections:FM-IFN-Artigos em Revistas Internacionais

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