Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/7615
Título: Life without geminin
Autor: Karamitros, Dimitris
Kotantaki, Panorea
Lygerou, Zoi
Fernandes, Henrique Veiga
Pachnis, Vassilis
Kioussis, Dimitris
Taraviras, Stavros
Palavras-chave: Geminin
Cdt1
Stem cells
Licensing
Self-renewa
Cell cycle duration
Data: 2010
Editora: Landes Bioscience
Citação: Cell Cycle 9:16, 3181-3185
Resumo: The interplay of proliferation and differentiation is essential for normal development and organogenesis. Geminin is a cell cycle regulator which controls licensing of origins for DNA replication, safeguarding genomic stability. Geminin has also been shown to regulate cellular decisions of self-renewal versus commitment of neuronal progenitor cells. We discuss here our recent analysis of mice with conditional inactivation of the Geminin gene in the immune system. Our data indicate that Geminin is not indispensable for every cell division: in the absence of Geminin, development of progenitor T cells appears largely unaffected. In contrast, rapid cell divisions, taking place in vitro upon TCR receptor activation or in vivo during homeostatic proliferation, are defective.
Descrição: © 2010 Landes Bioscience
Peer review: yes
URI: http://dx.doi.org/10.4161/cc.9.16.12554
http://hdl.handle.net/10451/7615
ISSN: 1538-4101
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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