Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/8153
Título: Release profile of ibuprofen in β-cyclodextrin complexes from two different solid dosage forms
Autor: Salústio, Paulo
Feio, Gabriel
Figueirinhas, João
Cabral-Marques, Helena
Costa, Paulo
Pinto, João
Palavras-chave: β-cyclodextrin
dissolution
ibuprofen
pellet
tablet
Data: Jan-2012
Citação: Powder Technology, Volume 221, May 2012, Pages 245-251
Resumo: The objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with β-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion process occurred in a same yield that when pre-complexation was used. The particles characteristics were evaluated after being obtained through different complexation methods. The results showed that the tensile strength and profile dissolution were as expected for both dosage forms. Tablets containing inclusion complexes showed higher solubility when compared with a reference formulation and with two commercial formulations. The ibuprofen released from the two pellets formulations didn’t show relevant differences between them. The drug released was analyzed considering different dissolution parameters. The advantages of these new methodologies can be summarized as: (a) tablets were produced at a lower cost for the total process; and (b) in the pellet´s preparation there was no need of the previous complexation method resulting in a decrease in time and energy required.
Peer review: yes
URI: http://dx.doi.org/10.1016/j.powtec.2012.01.008
http://hdl.handle.net/10451/8153
http://www.sciencedirect.com/science/article/pii/S0032591012000113
ISSN: 0032-5910
Versão do Editor: http://dx.doi.org/10.1016/j.powtec.2012.01.008
Aparece nas colecções:FF - Artigos em Revistas Internacionais

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