Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/8188
Título: Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
Autor: Quiroz, César
Gomes, Catarina
Pak, Arlene C.
Ribeiro, Joaquim A.
Goldberg, Steven R.
Hope, Bruce T.
Ferré, Sergi
Palavras-chave: Caffeine
Adenosine A2A receptor
Striatum
Phosphorylation
ERK1/2
AMPA receptor
Data: 2006
Editora: Society for Neuroscience
Citação: The Journal of Neuroscience, October 18, 2006 • 26(42):10808 –10812
Resumo: Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP– protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogenactivated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.
Descrição: ©2006 Society for Neuroscience
Peer review: yes
URI: http://dx.doi.org/10.1523/JNEUROSCI.1661-06.2006
http://hdl.handle.net/10451/8188
ISSN: 0270-6474
Aparece nas colecções:FM-IFN-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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